Jelena Jankovic, the 2007 Family Circle Cup champion and No. 2 seed, scored a straight set, 6-0, 6-3 victory over American Lauren Davis Wednesday. No. 3 seed Sara Errani and No. 4 seed Sabine Lisicki also advanced.

Errani moved on when Kiki Bertems retired with a lower back injury after losing the first set, 6-3. Vania King took Lisicki to three sets but the 2009 Family Circle Cup champion outlasted the American, 7-5, 4-6, 6-3.

Earlier Wednesday, another high-seeded American was upset; No. 5 Sloane Stephens dropped a 6-4, 6-4 stadium court match to Elina Svitolina.

Top seed Serena Williams lost Tuesday night. No. 15 seed Madison Keys dropped a three-set match to Shuai Peng.

Venus Williams rallied for a 7-5, 7-5 victory over Chanelle Scheepers after Scheepers led 4-1 in the second set.

Later Wednesday, No. 3 Sara Errani and No. 11 Venus Williams were scheduled for matches.

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No. 3 Sara Errani def. Kiki Bertens, 6-3, retired

Shuai Peng def. No. 15 Madison Keys 6-1, 6-7, 7-6

No. 4 Sabine Lisicki def. Vania King, 7-5, 4-6, 6-3

Elina Svitlolina def. No. 5 Sloane Stephens, 6-4, 6-4

No. 13 Elena Vesnina def. Petra Cetkovska, 3-6, 6-2, 6-4

No. 12 Daniela Hantuchova def. Grace Min, 6-2, 6-3

No. 3 Sara Errani def. Kiki Bertens, 6-3, ret. injury

No. 11 Venus Williams def. Chanelle Scheepers, 7-5, 7-5

No. 2 Jelena Jankovic def. Lauren Davis, 6-0, 6-3